Plasma Cannabinoid Pharmacokinetics following Controlled Oral -Tetrahydrocannabinol and Oromucosal Cannabis Extract Administration
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چکیده
BACKGROUND: Sativex , a cannabis extract oromucosal spray containing -tetrahydrocannabinol (THC) and cannabidiol (CBD), is currently in phase III trials as an adjunct to opioids for cancer pain treatment, and recently received United Kingdom approval for treatment of spasticity. There are indications that CBD modulates THC’s effects, but it is unclear if this is due to a pharmacokinetic and/or pharmacodynamic interaction.
منابع مشابه
Plasma cannabinoid pharmacokinetics following controlled oral delta9-tetrahydrocannabinol and oromucosal cannabis extract administration.
BACKGROUND Sativex(®), a cannabis extract oromucosal spray containing Δ(9)-tetrahydrocannabinol (THC) and cannabidiol (CBD), is currently in phase III trials as an adjunct to opioids for cancer pain treatment, and recently received United Kingdom approval for treatment of spasticity. There are indications that CBD modulates THC's effects, but it is unclear if this is due to a pharmacokinetic an...
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A multitude of roles for the endogenous cannabinoid system has been proposed by recent research efforts. A large number of endogenous cannabinoid neurotransmitters or endocannabinoids have been identified, and the CB-1 and CB-2 cannabinoid receptors have been characterized. The presence of other receptors, transporters, and enzymes responsible for the synthesis or metabolism of endocannabinoids...
متن کاملOral Fluid and Plasma Cannabinoid Ratios after Around-the-Clock Controlled Oral -Tetrahydrocannabinol Administration
METHODS: Ten male daily cannabis smokers received around-the-clock escalating 20-mg oral tetrahydrocannabinol (THC, dronabinol) doses (40 – 120 mg/day) for 8 days. Plasma and OF samples were simultaneously collected before, during, and after dosing. OF THC, 11-hydroxy-THC and 11-nor-9carboxy-THC (THCCOOH) were quantified by GC-MS at 0.5g/L, 0.5g/L, and 7.5-ng/L limits of quantification (LOQs), ...
متن کاملPharmacokinetics and pharmacodynamics of cannabinoids.
Delta(9)-Tetrahydrocannabinol (THC) is the main source of the pharmacological effects caused by the consumption of cannabis, both the marijuana-like action and the medicinal benefits of the plant. However, its acid metabolite THC-COOH, the non-psychotropic cannabidiol (CBD), several cannabinoid analogues and newly discovered modulators of the endogenous cannabinoid system are also promising can...
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تاریخ انتشار 2010